Author: Fu-Peng Wu, Yang Yuan, Jiawang Liu and Xiao-Feng Wu*
Angewandte Chemie International Edition DOI:10.1002/anie.202017365
Abstract：An unprecedented and challenging defluorinative carbonylation was achieved. Enabled by Pd/Cu cooperated catalyst system, the first example on defluorinative carbonylative coupling has been established. With gem-difluoroalkenes and aryl iodides as the substrates, this methodology offers a flexible and facile access to privileged-fluorochalcones under mild reaction conditions in moderate to excellent yields. Mechanistic studies indicated transmetalation between palladium and copper intermediates as a crucial step of the catalytic cycle.
